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4 Apr 2016 Dr. Marina, Goumenou, Scope and ethical principles of toxicology and 3R, EUROTOX Introduction to Toxicology, the Dose-Response and Basic Concepts, http://apps.who.int/iris/bitstream/10665/44065/8/WHO_EHC_240_8_eng_Chapter5.pdf Principles and Methods of Toxicology (A. W. Hayes, ed.).